Welcome

Aging is a decline in homeostatic capacity that results in an increased susceptibility to disease and death. Interestingly, there are genetic elements that regulate lifespan in yeast which have been found to have similar effects on mammalian longevity.  Our research into yeast aging aims to unravel the cellular transformations that occur with aging and identify pathways that drive the aging process. This research can help lead to pinpointing potential therapeutic targets for combating age-associated diseases.  Additionally, we are pioneering yeast-based systems that will allow for the discovery of novel medications that can impede known biological pathways implicated in aging, in order to increase healthspan.

Maintaining a stable internal cellular environment, known as cellular homeostasis, is vital for optimal health and disease prevention. Our laboratory focuses on understanding the impact of changes in cellular pH balance on the physiology of cells. Utilizing the unparalleled genetic resources available in yeast, we can unbiasedly discover genes and pathways that facilitate adaptive survival when cellular equilibrium is disturbed.

We have developed course-based undergraduate research experiences (CUREs) using CRISPR.  The series of laboratory experiments are designed to equitably provide students with authentic scientific research experiences by allowing students to formulate their own novel hypotheses and to ask questions with unknown answers.  We also develop stand-alone laboratory exercises (e.g., genetic engineering using CRISPR to generate  red yeast).  Email (cure at wasko.org) if you are interested in detailed protocols, reagents, etc. 

Find our CURE protocols and bioinformatic tools here.